Brief Bio of Dr. William Yang
William H. Yang, MD, FRCPC, FAAAAI
Chair, Red Maple Trials Inc.
Ottawa, Ontario, Canada
Dr. William Yang, MD, FRCPC, FAAAAI, has been active in clinical practice, research and teaching in Ottawa. He completed his Internal Medicine training at the University of Western Ontario and Allergy and Clinical Immunology research training at McGill University. He is the former head, Section of Allergy & Clinical Immunology, University of Ottawa Medical School. He is a past President of the Canadian Society of Allery & Clinical Immunology, a Fellow of the Royal College of Physicians & Surgeons of Canada and American Academy of Allergy, Asthma & Clinical Immunology.
Dr. Yang’s early research has led him to discover the allergen in soybean protein, a research article was later published in the New England Journal of Medicine. Subsequent research in metabisulfite, a preservative in food, beverages and salad bars, has made him well recognized in the field nationally and internationally. He managed single-handedly to convince the government to ban the use of metabisulfite in the salads to protect asthmatics and allergy sufferers in this country. He was instrumental in raising the awareness of increasing mortality and morbidity in the country, asking government to fund workshops throughout the country, leading to the subsequent publication of the Canadian Asthma Consensus Guidelines.
He is the founder of Ottawa Allergy Research Corporation. He has also published over three hundred abstracts, manuscripts and book chapters in peer reviewed journals. He is actively involved in clinical trials for biotechnology and pharmaceutical companies. He is active in vaccine development involving H1N1, influenza, Covid etc. His research interest is also in hereditary angioedema (HAE) for over the last three decades, raising the HAE disease awareness and providing education for patients and health care providers and developing new treatment options for HAE sufferers. Yang Medicine is recognized as the Treatment and Reference Centre for HAEi International.
Also, a founder of Yang Medicine Yang Medicine Professional Corporation. It is recognized as Treatment (Biologic therapy) Centre of Excellence by the industry.
He co-founded Red Maple Trials Inc (RMT) which provides end-to-end services in allergy, asthma and immunology clinical research. RMT possess next generation clinical trial facilities highlighted by an Allergen Challenge Theatre plus a specialty focus CRO in allergy, asthma & clinical immunology, located in the nation’s capital. RMT is capable of executing on Phase 1-4 studies with 15 beds, in order to fulfill the challenging demands of our biopharmaceutical partners.
Currently, in additional to HAE and vaccine research, he is active in studies on severe asthma, eosinophilic esophagitis (EoE), peanut allergy, atopic dermatitis, chronic spontaneous urticaria etc.
Notable Publications
Food Allergy
Allergic Rhinitis & Asthma
HAE
Article Topics
Manuscripts of Interest
Food
Dust Mites
Challenge Theatre
Chronic Spontaneous Urticaria/Chronic Idiopathic Urticaria (CSU/CIU)
Ragweed and Pollen
Development and validation of an Allergen Challenge Theater for grass and ragweed
Patient Responses to Ragweed Challenge Validate The Allergen Challenge Theatre
Response to ragweed provocation in the Red Maple Trials Allergen Challenge Theatre
Methodology for predicting air-borne pollen in Canadian cities
Cat
Controlled Dander Aerosolization in a Naturalistic Exposure Chamber
Validation of a cat dander Naturalistic Exposure Chamber (NEC)
Automated Dander Dispersion in a Naturalistic Exposure Chamber
A Numerical Evaluation of Cat Dander Levels by Safranin-O Staining
Cat Natural Exposure Chamber (NEC) Rhinoconjunctivitis Study
Development of a Method to Evaluate Cat Dander Levels by Safranin-0 Staining
Aerosolization of Cat Dander in a Naturalistic Exposure Chamber
Validation of a cat allergen exposure chamber for patients with perennial allergic rhinitis to cats
Validation of air sampling technique for control of Fel d1 levels in cat allergen exposure chamber
Stabilizing Fel d1 Levels in a Cat Allergen Exposure Chamber
Anatomic Distribution of Fel D1 and Fel D4 in Domestic House Cats
Methods For Homogenizing Fel D1 Levels in a Cat Allergen Exposure Chamber
Control of Fel D 1 Levels in a Cat Allergen Exposure Chamber
Fel d 1 and fel d 4 allergen levels in fur, urine, and saliva of domestic house cats
Is There a Time-Dependent Association Between Cat Dander Sampling Time and Feld1 Levels?
Assessment of Fel d1 allergen characteristics in domestic house cats
Development of a method to evaluate cat dander levels by light microscopy
Commissioning of a Larger Naturalistic Exposure Chamber for Cat Dander
Automated dander dispersal in a cat Naturalistic Exposure Chamber (NEC)
Hereditary Angioedema (HAE)
Effect of Lanadelumab Compared with Placebo on Prevention of Hereditary Angioedema Attacks
Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor
Self-administration of Intravenous C1 Esterase Inhibitor in Hereditary Angioedema
Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema
Real World Data of Canadians Living with Hereditary Angioedema: Part 1 - Demographics
Real World Data of Canadians Living with Hereditary Angioedema: Part 2 - Attack Profile
Real World Data of Canadians Living with Hereditary Angioedema: Part 3 - Treatment Utilization
Real World Data of Canadians Living with Hereditary Angioedema: Part 4 - Patient Satisfaction
Lanadelumab Reduces HAE Attack Rate: Interim Findings From the HELP Open-Label Extension Study
The prophylactic use of C1 esterase inhibitor in HAE patients undergoing invasive procedures
Early presentation of clinical hereditary angioedema symptoms in an infant
Real World Data of Canadian Adults Living with Angioedema: Part 4 - Health Economic Burden
Real world data of Canadians living with hereditary angioedema (HAE): Attributes of new medications
Lanadelumab inhibition of plasma kallikrein activity for effective HAE prophylaxis
Peanut
Perennial Allergic Rhinitis/Seasonal Allergic Rhinitis (PAR/SAR)
Asthma
Rhinoconjunctivitis/Rhinosinusitis
Faster onset of action with topical levocabastine than with oral cetirizine
Circulating Immune Complexes May Be Associated with Increased T-Cell Activity in Atopic Allergy
Efficacious use of omalizumab in the treatment of cystic fibrosis
Omalizumab can be effective in patients with allergic bronchopulmonary aspergillosis
A case of acquired angioedema associated with Waldenstrom’s macroglobulinemia treated with rituximab
Other